GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12196860 | 1 | rs12198225 | chr6:55947475 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -7.01 | 4.22E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12198637 | chr6:55981400 | COL21A1 | chr6:55921389-56258892:- | -0.36 | -6.64 | 5.09E-11 | Psychosis (atypical) |
| BRCA | cis | rs2274459 | 1 | rs12199132 | chr6:33708250 | IP6K3 | chr6:33689443-33714762:- | 0.24 | 4.21 | 2.74E-5 | Obesity (extreme) |
| BRCA | cis | rs1577917 | 1 | rs12199516 | chr6:86726221 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -18.48 | 2.18E-66 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12199784 | chr6:86726808 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -18.47 | 2.46E-66 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12200330 | chr6:86656653 | SNHG5 | chr6:86386726-86388451:- | -0.61 | -18.81 | 2.08E-68 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12200525 | chr6:55982301 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.86 | 1.14E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12200667 | chr6:55982461 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.86 | 1.14E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12201413 | chr6:55933348 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs1577917 | 1 | rs12201571 | chr6:86609750 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -18.42 | 5.21E-66 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12201735 | chr6:86656939 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -18.08 | 6.09E-64 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12201741 | chr6:86602619 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -17.68 | 1.46E-61 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12201880 | chr6:86627007 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -17.95 | 3.91E-63 | Response to antipsychotic treatment |
| BRCA | cis | rs9473555 | 1 | rs12202075 | chr6:49427655 | CENPQ | chr6:49431096-49460820:+ | -0.24 | -7.97 | 4.15E-15 | Folate pathway vitamin levels |
| BRCA | cis | rs9473555 | 1 | rs12202075 | chr6:49427655 | MUT | chr6:49398994-49431031:- | 0.32 | 10.25 | 1.42E-23 | Folate pathway vitamin levels |